Fig 5.

Lung CD11c⁺ cells are the main producers of IFN-β at late stages of infection with wild-type SC35M. Conditional reporter mice selectively expressing luciferase in epithelial cells (Nkx), macrophages/monocytes (LysM), CD11c⁺ cells (CD11c), or macrophages/monocytes and CD11c⁺ cells (LysM/CD11c) were infected with wild-type SC35M, and luciferase activity in lungs was determined at the indicated time points. Values represent means ± SEM for groups of animals (n ≥ 6) from each time point. (B) Luciferase values from infected conditional mice expressing the reporter gene in the indicated cell types were compared to luciferase values from infected global reporter mice. Values from global reporter mice were set to 100% and depicted as full-sized pies at each time point. The sizes of the pies are proportional to total luciferase activity at a particular time point postinfection.