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. 2013 Jun;87(12):6700–6712. doi: 10.1128/JVI.00655-13

Table 1.

Features of predicted protein-coding regions in EEHV1A and EEHV1B

EEHV1 ORF HCMV ortholog Identitya (%) ORF family Protein nameb Protein description
EE1 95 Protein EE1
EE2 99 Protein EE2
EE3 32 EE3 Protein EE3 Contains signal peptide
EE4 42 EE3 Protein EE4 Contains signal peptide
EE5 51 Protein EE5 Contains signal peptide
U82 UL115 70 Envelope glycoprotein L Contains signal peptide; complexed with envelope glycoprotein H; involved in cell entry; involved in cell-to-cell spread
U81 UL114 73 Uracil-DNA glycosylase Involved in DNA repair
EE6c Protein EE6 Contains signal peptide
U79 UL112 89 Protein UL112 Involved in gene regulation; involved in DNA replication
U77 UL105 100 Helicase-primase helicase subunit Involved in DNA replication
U76 UL104 100 Capsid portal protein Dodecamer located at one capsid vertex in place of penton; involved in DNA encapsidation
U75 UL103 98 Tegument protein UL7* Involved in virion morphogenesis
U74 UL102 98 Helicase-primase subunit Involved in DNA replication
U73 98 DNA replication origin-binding helicase Involved in DNA replication
U72 UL100 97 Envelope glycoprotein M Type 3 membrane protein; 8 transmembrane domains; complexed with envelope glycoprotein N; involved in virion morphogenesis; involved in membrane fusion
U71 UL99 91 Myristylated tegument protein Envelope-associated; involved in virion morphogenesis
U70 UL98 98 DNase Involved in DNA processing
U69 UL97 100 Tegument serine/threonine protein kinase Involved in protein phosphorylation
U68 UL96 100 Tegument protein UL14* Involved in virion morphogenesis
U67 UL95 100 Protein UL95 Promotes accumulation of late transcripts
U65 UL94 96 Tegument protein UL16* Possibly involved in virion morphogenesis
U64 UL93 99 DNA packaging tegument protein UL17* Capsid-associated; involved in DNA encapsidation; involved in capsid transport
U63 UL92 99 Protein UL92
U62 UL91 99 Protein UL91
U60 UL89 99 DNA packaging terminase subunit 1 Contains ATPase domain; involved in DNA encapsidation
U59 UL88 100 Tegument protein UL88
U58 UL87 100 Protein UL87 Promotes accumulation of late transcripts
U57 UL86 99 Major capsid protein 6 copies form hexons, 5 copies form pentons; involved in capsid morphogenesis
U56 UL85 99 Capsid triplex subunit 2 Complexed 2:1 with capsid triplex subunit 1 to connect capsid hexons and pentons; involved in capsid morphogenesis
U54 UL82/UL83/UL84 98 DURP Protein U54
U53.5 UL80.5 100 Capsid scaffold protein Clipped near C terminus; involved in capsid morphogenesis
U53 UL80 100 Capsid maturation protease Serine protease (N-terminal region); minor scaffold protein (remainder of protein, clipped near C terminus); involved in capsid morphogenesis
U52 UL79 100 Protein UL79 Promotes accumulation of late transcripts
U51 UL78 98 Envelope protein UL78 Type 3 membrane protein; 7 transmembrane domains; similar to GPCRs; putative chemokine receptor; possibly involved in intracellular signaling
U50 UL77 98 DNA packaging tegument protein UL25* Located on capsid near vertices; possibly stabilizes the capsid and retains the genome; involved in DNA encapsidation
U49 UL76 100 Nuclear protein UL24*
EE7 82 Thymidine kinase Involved in nucleotide metabolism
U48 UL75 66 Envelope glycoprotein H Type 1 membrane protein; possible membrane fusogen; complexed with envelope glycoprotein L; involved in cell entry; involved in cell-to-cell spread
U47 UL74 63 Envelope glycoprotein O Associated with envelope glycoprotein H and envelope glycoprotein L; involved in virion morphogenesis
U46 UL73 82 Envelope glycoprotein N Type 1 membrane protein; complexed with envelope glycoprotein M; involved in virion morphogenesis; involved in membrane fusion
EE8 74 Protein EE8 Contains potential transmembrane domain
U27 UL44 99 DNA polymerase processivity subunit dsDNA-binding protein; involved in DNA replication
EE9 100 Ribonucleotide reductase subunit 2 Involved in nucleotide metabolism
U28 UL45 100 Ribonucleotide reductase subunit 1 Involved in nucleotide metabolism
U29 UL46 99 Capsid triplex subunit 1 Complexed 1:2 with capsid triplex subunit 2 to connect capsid hexons and pentons; involved in capsid morphogenesis
U30 UL47 98 Tegument protein UL37* Complexed with large tegument protein; involved in virion morphogenesis
U31 UL48 96 Large tegument protein Complexed with tegument protein UL37; ubiquitin-specific protease (N-terminal region); involved in capsid transport
U32 UL48A 89 Small capsid protein Located externally on capsid hexons; involved in capsid morphogenesis; possibly involved in capsid transport
U33 UL49 99 Protein UL49
U34 UL50 100 Nuclear egress membrane protein Type 2 membrane protein; interacts with nuclear egress lamina protein; involved in nuclear egress
U35 UL51 100 DNA packaging protein UL33* Interacts with DNA packaging terminase subunit 2; involved in DNA encapsidation
U36 UL52 100 DNA packaging protein UL32* Involved in DNA encapsidation; possibly involved in capsid transport
U37 UL53 100 Nuclear egress lamina protein Interacts with nuclear egress membrane protein; involved in nuclear egress
U38 UL54 97 DNA polymerase catalytic subunit Involved in DNA replication
U39 UL55 87 Envelope glycoprotein B Type 1 membrane protein; possible membrane fusogen; binds cell surface heparan sulfate; involved in cell entry; involved in cell-to-cell spread
U40 UL56 100 DNA packaging terminase subunit 2 Involved in DNA encapsidation
U41 UL57 100 Single-stranded DNA-binding protein Contains zinc finger; involved in DNA replication; possibly involved in gene regulation
U42 UL69 100 Multifunctional expression regulator RNA-binding protein; shuttles between nucleus and cytoplasm; inhibits pre-mRNA splicing; exports virus mRNA from nucleus; exerts most effects posttranscriptionally; involved in gene regulation; involved in RNA metabolism and transport
U43 UL70 99 Helicase-primase primase subunit Involved in DNA replication
U44 UL71 100 Tegument protein UL51* Involved in virion morphogenesis
EE10 99 Protein EE10
EE11 100 UL27 Protein EE11
U4 UL27 100 UL27 Protein UL27
U11 UL32 99 Tegument protein pp150 Major tegument protein; binds to capsids
U12 UL33 100 Envelope glycoprotein UL33 Type 3 membrane protein; 7 transmembrane domains; similar to GPCRs; putative chemokine receptor; involved in intracellular signaling
UL34 UL34 100 Protein UL34 Involved in gene regulation
U14 UL35 95 Tegument protein UL35
EE12 94 Protein EE12 Contains potential transmembrane domain
EE13 100 Protein EE13 Contains US22 domain
EE14 100 Protein EE14
EE15 90 Protein EE15 Contains potential transmembrane domain
EE16 62 Protein EE16 Contains signal peptide
EE17 72 Protein EE17 Contains signal peptide
EE18 99 7TM Membrane protein EE18 Type 3 membrane protein; 7 transmembrane domains
EE19 99 7TM Membrane protein EE19 Type 3 membrane protein; 7 transmembrane domains
EE20 100 EE20 Membrane protein EE20 Type 2 membrane protein
EE21 99 7TM Membrane protein EE21 Type 3 membrane protein; 7 transmembrane domains; similar to GPCRs
EE22 78 OX-2 Membrane protein EE22 Type 2 membrane protein; contains 2 immunoglobulin domains; similar to OX-2 (CD200)
EE23 100 OX-2 Protein EE23 Contains signal peptide; contains immunoglobulin domain; similar to OX-2 (CD200)
EE24 100 Protein EE24 Contains potential transmembrane domain
EE25 99 Protein EE25 Contains potential transmembrane domain
EE26 94 7TM Membrane protein EE26 Type 3 membrane protein; 7 transmembrane domains; similar to GPCRs
EE27 100 Protein EE27
EE28 100 7TM Membrane protein EE28 Type 3 membrane protein; 7 transmembrane domains; similar to GPCRs
EE29 100 DURP Protein EE29
EE30 98 Protein EE30
EE31 96 7TM Membrane protein EE31 Type 3 membrane protein; 7 transmembrane domains
EE32 90 EE20 Protein EE32 Contains potential transmembrane domain
EE33 100 7TM Membrane protein EE33 Type 3 membrane protein; 7 transmembrane domains
EE34 99 7TM Membrane protein EE34 Type 3 membrane protein; 7 transmembrane domains; similar to GPCRs
EE35 100 7TM Membrane protein EE35 Type 3 membrane protein; 6 transmembrane domains
EE36 99 7TM Membrane protein EE36 Type 3 membrane protein; 7 transmembrane domains
EE37 100 7TM Membrane protein EE37 Type 3 membrane protein; 7 transmembrane domains
EE38 100 7TM Membrane protein EE38 Type 3 membrane protein; 7 transmembrane domains
EE39 99 7TM Membrane protein EE39 Type 3 membrane protein; 7 transmembrane domains
EE40e 97g 7TM Membrane protein EE40 Type 3 membrane protein; 7 transmembrane domains
EE41 99 7TM Membrane protein EE41 Type 3 membrane protein; 7 transmembrane domains
EE42 100 7TM Membrane protein EE42 Type 3 membrane protein; 7 transmembrane domains
EE43 100 7TM Membrane protein EE43 Type 3 membrane protein; 7 transmembrane domains
EE44e,f 75g Protein EE44 Contains signal peptide
EE45 93 7TM Membrane protein EE45 Type 3 membrane protein; 8 transmembrane domains; similar to GPCRs
EE46 99 β-1,3-Galactosyl-O-glycosyl-glycoprotein β-1,6-N-acetylglucosaminyltransferase Contains potential transmembrane domain; involved in protein glycosylation
EE47 95 7TM Membrane protein EE47 Type 3 membrane protein; 8 transmembrane domains; similar to GPCRs
EE48 99 7TM Membrane protein EE48 Type 3 membrane protein; 7 transmembrane domains
EE49 96 7TM Membrane protein EE49 Type 3 membrane protein; 8 transmembrane domains
EE50 100 EE50 Membrane protein EE50 Contains signal peptide; contains immunoglobulin domain
EE51 97 OX-2 Membrane protein EE51 Type 2 membrane protein; contains 2 immunoglobulin domains; similar to OX-2 (CD200)
EE52 88 EE50 Membrane protein EE52 Type 2 membrane protein; contains immunoglobulin domain
EE53f 45g EE50 Membrane protein EE53 Type 2 membrane protein; contains immunoglobulin domain
EE54d EE50 Membrane protein EE54 Type 2 membrane protein
EE55d,e EE50 Membrane protein EE55 Type 2 membrane protein
EE56d EE50 Membrane protein EE56 Type 2 membrane protein
EE57e,f 82g EE50 Membrane protein EE57 Type 2 membrane protein; contains immunoglobulin domain
EE58e 51g EE50 Membrane protein EE58 Type 2 membrane protein
EE59f,h 7TM Membrane protein EE59 Type 3 membrane protein; 7 transmembrane domains
EE60c,f EE50 Membrane protein EE60 Type 2 membrane protein; contains immunoglobulin domain
EE61c,f EE50 Membrane protein EE61 Type 2 membrane protein
EE62c 7TM Membrane protein EE62 Type 3 membrane protein; 7 transmembrane domains
EE63 58 α-(1,3)-Fucosyltransferase Contains potential transmembrane domain; involved in protein glycosylation
a

Calculated from EEHV1A and EEHV1B amino acid sequences aligned by using GCG Gap and shown to the nearest integer.

b

The standard nomenclature for orthologous herpesvirus proteins employed in NCBI Reference Sequence files is used for conserved ORFs. In this system, the names of proteins specified by certain ORFs are derived from HCMV nomenclature (e.g., tegument protein UL35, encoded by U14). However, the names of proteins specified by certain core ORFs are derived from nomenclature of the alphaherpesvirus herpes simplex virus type 1 (e.g., DNA packaging tegument protein UL25, encoded by U50). Names in the latter category may cause confusion in relation to HCMV ORF nomenclature and are marked by asterisks.

c

ORF absent from EEHV1B.

d

ORF absent from EEHV1A.

e

Fragmented in EEHV1B.

f

Fragmented in EEHV1A.

g

Repaired, nonfragmented sequences used.

h

EEHV1A ORF too fragmented to be repaired.