Fig 2.

(A) NAb titers present in mouse sera 7, 10, and 21 days after vaccination with the wild type or the attenuated HR mutant ChikV 37997. (B) Total anti-ChikV IgG (OD₄₅₀) present in mouse serum 21 days postvaccination. The NAb titers represent the geometric means of sera from 3 different mice per group per day. The amount of total WT IgG measured was found to be statistically larger than that of the IgG from TM17-1 and -3 (P ≤ 0.03 for naïve; P ≤ 0.02 for TM17-1; P ≤ 0.04 for TM17-3), while no significant difference was found among the respective mutant pairs. There was no significant difference between WT and TM17-2, whereas TM17-2 was statistically higher than mock (P ≤ 0.03). The error bars indicate standard deviations within sample groups.