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. 2013 Jun;87(12):6748–6757. doi: 10.1128/JVI.03357-12

Fig 5.

Fig 5

Pathology of mouse foot/ankle joint histology sections 7 days postchallenge (magnification, ×20) of a representative animal. (A) Naive mice challenged with ChikV SL15649 displayed moderate muscle inflammation and necrosis. (B) Mice vaccinated with TM17-1 and challenged with ChikV SL15649 displayed minimal muscle inflammation. (C and D) Mice vaccinated with TM17-2 prior to challenge with ChikV SL15649 (C) displayed no notable pathology, similar to samples obtained from naive mock-challenged animals (D). Bar, 50 μm.