Table 2.
Persistence of ChikV RNA in mouse tissue after vaccination
| Vaccine group | Mice testing positivea |
|||||
|---|---|---|---|---|---|---|
| 10 days p.i. |
21 days p.i. |
|||||
| Serum | Foot/ankle | Quadriceps | Serum | Foot/ankle | Quadriceps | |
| WT ChikV | + | +++ | + | + | +++ | + |
| TM17-1 | − | − | − | − | + | − |
| TM17-2 | − | − | − | + | − | − |
| TM17-3 | ++ | − | − | ++ | − | − |
| Naive | − | − | − | − | − | − |
a
The number of plus signs represents the number of mice per sample group that tested positive (n = 3). A minus sign means all mice tested negative. The limit of detection was 12.8 pg RNA/reaction, or ∼10 PFU.