Table 3.
Viremia detected in mouse tissue after challenge with ChikV SL15649
| Vaccine | Viremiaa (PFU/ml) |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Serum |
Foot/ankle |
Quadriceps |
|||||||
| Day 1 | Day 2 | Day 3 | Day 1 | Day 2 | Day 3 | Day 1 | Day 2 | Day 3 | |
| TM17-1 | 1.3 × 104 | ND | ND | ND | ND | ND | ND | 6.4 × 102) | ND |
| (P < 0.05) | (NS) | (NS) | (P < 0.05) | (P < 0.001) | (P < 0.05) | (P < 0.01) | (P < 0.01) | (NS) | |
| TM17-2 | ND | ND | ND | ND | ND | ND | ND | ND | ND |
| (P < 0.001) | (P < 0.001) | (NS) | (P < 0.05) | (P < 0.001) | (P < 0.05) | (P < 0.001) | (P < 0.01) | (NS) | |
| ChikV 37997 | ND | ND | ND | 8.5 × 103 | ND | ND | 5.1 × 102 | 1.3 × 104 | ND |
| (P < 0.001) | (P < 0.01) | (NS) | (P < 0.001) | (P < 0.001) | (P < 0.05) | (P < 0.001) | (P < 0.01) | (NS) | |
| Naive | 4.7 × 107 | 8.6 × 105 | ND | 4.3 × 103 | 7.3 × 103 | 9.8 × 102 | 1.7 × 105 | 4.0 × 105 | 2.1 × 103 |
a
ND, below the detection limit of the assay (40 PFU/ml); NS, not statistically significant. The P values demonstrate significant difference from the naive control group.