Table 1.
Varicella-zoster virus ORFsa
| VZV gene | Molecular mass (kDa) |
Function | Localization in infected cells | HSV-1 ortholog | |
|---|---|---|---|---|---|
| Calculated | Apparent | ||||
| Orf0(S/L) | 14.1 | Membrane-associated protein | NA | UL56 | |
| Orf1 | 12.1 | 16–20 | Tail-anchored membrane phosphoprotein | Golgi/M | None |
| Orf2 | 24.1 | 28 | Membrane-associated phosphoprotein | Golgi network | None |
| Orf3 | 19.1 | 19 | Potential role in gene expression | N≫C | UL55 |
| Orf4 | 51.5 | 60 | Transactivator | N | UL54 |
| Orf5 | 38.6 | 55 | Glycoprotein K | Golgi/M | UL53 |
| Orf6 | 122.6 | 125 | DNA helicase-primase complex | N | UL52 |
| Orf7 | 28.2 | 35 | Virion phosphoprotein | Golgi network | UL51 |
| Orf8 | 44.8 | 50 | dUTPase | N≫C | UL50 |
| Orf9 | 32.9 | 35 + 50 | Tegument protein | C | UL49 |
| Orf9a | 9.8 | Glycoprotein N | NA | UL49a | |
| Orf10 | 46.6 | 50 | Transactivator | NA | UL48 |
| Orf11 | 91.8 | 110 | Tegument protein | Golgi/M | UL47 |
| Orf12 | 74.3 | 80b | Tegument protein | Golgi/M | UL46 |
| Orf13 | 34.5 | 35 | Thymidylate synthetase | Golgi/M | None |
| Orf14 | 61.4 | 70 | Glycoprotein C | Golgi network | UL44 |
| Orf15 | 44.5 | Membrane protein | NA | UL43 | |
| Orf16 | 46.1 | 46 | DNA polymerase-associated protein | N≫C | UL42 |
| Orf17 | 51.4 | Host shutoff protein | N≫C | UL41 | |
| Orf18 | 35.4 | 36 | Ribonucleotide reductase (small SU) | NA | UL40 |
| Orf19 | 86.8 | 90 | Ribonucleotide reductase (large SU) | NA | UL39 |
| Orf20 | 54 | 55 | Capsid protein | N≫C | UL38 |
| Orf21 | 115.8 | 120 | Tegument protein | Golgi/M | UL37 |
| Orf22 | 306.3 | 310b | Tegument protein | Golgi/M | UL36 |
| Orf23 | 24.4 | 35 | Capsid protein | N | UL35 |
| Orf24 | 23.8 | 32 + 60 | Nuclear egress complex | N | UL34 |
| Orf25 | 17.5 | 20 | DNA packaging protein | N≫C | UL33 |
| Orf26 | 65.7 | 80 | Virion protein | N | UL32 |
| Orf27 | 35.7 | 40 | Nuclear egress complex | N | UL31 |
| Orf28 | 134.1 | DNA polymerase | NA | UL30 | |
| Orf29 | 132.1 | SS-DNA binding protein | NA | UL29 | |
| Orf30 | 87 | Virion protein | NA | UL28 | |
| Orf31 | 105.4 | 65 + 125 | Glycoprotein B | Golgi/M | UL27 |
| Orf32 | 16 | 18 + 20 | Potential regulatory role in replication | N | None |
| Orf33 | 66 | 30/34 + 66/80b | Protease, scaffold | N | UL26 |
| ORF33.5 | 32.8 | 30/34b | Scaffold | N | UL26.5 |
| Orf34 | 65.2 | Virion protein | NA | UL25 | |
| Orf35 | 29 | Virion protein | NA | UL24 | |
| Orf36 | 37.8 | 38 | TK | NA | UL23 |
| Orf37 | 93.7 | 100 + 110 | Glycoprotein H | NA | UL22 |
| Orf38 | 60.4 | Tegument protein | NA | UL21 | |
| Orf39 | 25.1 | 28 | Membrane protein | Golgi/M | UL20 |
| Orf40 | 155 | 155 | Major capsid protein | NA | UL19 |
| Orf41 | 34.4 | 35 | Capsid protein | NA | UL18 |
| Orf42 | 82.8 | Terminase | NA | UL15 | |
| Orf43 | 74 | Tegument protein | NA | UL17 | |
| Orf44 | 40.3 | 41b | Tegument protein | N≫C | UL16 |
| Orf45 | 40.2 | DNA packaging protein | NA | UL15 | |
| Orf46 | 22.6 | 28 | Minor tegument protein | NA | UL14 |
| Orf47 | 57.4 | 60 | S/T kinase | C | UL13 |
| Orf48 | 61.3 | 65 | DNase | N | UL12 |
| Orf49 | 8.9 | 15 | Myristylated virion protein | Golgi/M | UL11 |
| Orf50 | 48.7 | 50–55 | Glycoprotein M | Golgi network | UL10 |
| Orf51 | 94.4 | 120b | Origin binding protein | NA | UL9 |
| Orf52 | 86.4 | 86 | DNA helicase-primase complex | NA | UL8 |
| Orf53 | 37.4 | 38 | Potential role in mitochondrial function | NA | UL7 |
| Orf54 | 86.8 | 90b | Virion protein | NA | UL6 |
| Orf55 | 98.9 | DNA helicase-primase complex | N≫C | UL5 | |
| Orf56 | 21.8 | 22 + 35 | Virion protein | N | UL4 |
| Orf57 | 8.1 | 12 | Membrane-associated protein | Golgi/M | none |
| Orf58 | 25.1 | 30 | Nuclear phosphoprotein | N | UL3 |
| Orf59 | 34.4 | 35 | Uracil DNA glycosylase | N | UL2 |
| Orf60 | 17.6 | 35 | Glycoprotein L | NA | UL1 |
| Orf61 | 50.9 | 55c | Transactivator | N | RL2 |
| Orf62 | 140 | 140 | Major transactivator | N≫C | RS1 |
| Orf63 | 30.5 | 35c | Cotransactivator | N≫C | US1 |
| Orf64 | 19.9 | 20 | Virion protein | N | US10 |
| Orf65 | 11.4 | 20 | Tegument phosphoprotein | Golgi network | US9 |
| Orf66 | 43.7 | 48 | S/T kinase | N≫C | US3 |
| Orf67 | 39.4 | 70b | Glycoprotein I | Golgi/M | US7 |
| Orf68 | 70 | 100b | Glycoprotein E | Golgi/M | US8 |
a
Calculated and apparent molecular masses, function, and localization as determined by using our antibody collection and a herpes simplex virus 1 ortholog. N, nucleus (nuclear localization includes the nuclear egress complex); C, cytoplasm; N≫C, majority in the nucleus; Golgi/M, Golgi network/membranes; NA, not analyzed; SU, subunit; TK, thymidine kinase; SS-DNA, single-stranded DNA; S/T, serine/threonine.
b
Possible degradation products or posttranslational processing/alternative translational initiation.
c
Possible higher-molecular-mass products.