Fig 4.

Immunization of lactating monkeys induces anti-V1V2 IgG antibodies in plasma and breast milk. (A to C) End titers of IgG antibodies against C.1086 V1V2 in the plasma and milk of animals vaccinated with the DNA prime/i.m. protein boost (A), the MVA prime/i.m. protein boost (B), and the MVA prime/i.n. protein boost (C) vaccine regimens. Each line represents one animal. Plasma is represented with filled symbols, and milk is represented with open symbols. (D to F) Correlation between end titers of IgG antibodies against C.1086 V1V2 and gp70V1V2 case A2 (D), gp70V1V2 case A2 V169K/E172V/E173H (E), and A244 V1V2 (F). The y axis represents log₁₀.