Table 2.
Common human HLAs predicted to bind epitope P1519a
| NV epitope or human class I HLA | Consensus sequence |
IEDD rank |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | GI | GII | |
| Norovirus GI | S | W | V | S | R | F | Y | Q | L | NA | NA |
| Norovirus GII | S | W | V | N | Q | F | Y | S,T | L | NA | NA |
| HLA-A*23:01 | Y | W, I | 0.45 | 0.7 | |||||||
| HLA-A*24:02 | Y | N, E, L, M, P,G | D, P | I, V | F | Q, N | E,K | I, L, F | 0.55 | 1.10 | |
| HLA-B*08:01 | G, L, I | K, R | E, Q, D, H, L, S, T, R, G, K | K, R | N, Q, H, I, L, Y, V, E, M, S, T, F | E, H, M, N, D, Q, S, T, Y | E, Q, H, S,L, V, D, T | L, F, M | 0.50 | 2.30 | |
| HLA-B*37:01 | K, Q | D, E, H, P, G, S, L | V, I, T, R, A, D, G, H, M | Q, K, Y, L | F, M, L, T, E, N, D, Q, G, H | I, L | 1.4 | 3.0 | |||
| HLA-C*04:01 | Y, P, F | D, H | D, E, P | A, H, M, T, R | V, I, L | A | K, S, H | L, F, M | 0.1 | 0.3 | |
| HLA-C*06:02 | I, F, K, Y | P, R | P, I, G, F, Y, K, N, A | P, E, D, Q, L | I, L, F, M, K | V, I, L, A, T, S | R, K, Q, N | Y, E, Q, N, R, G, T, S, K | L, I, V, Y | 0.4 | 0.9 |
| HLA-C*07:02 | Y, P, R, D | P, G, A | D, E, V, Q, P, S, G | V, Y, I, L, F, M, T | V, I, L, M A, R | Y, M, N, R, V, F, E | H, A, F, D, K | Y, F, L | 0.2 | 0.7 | |
a
The consensus sequence for each epitope and HLA binding preference are shown. Underlined residues denote preferred anchors at the given position (63). The Immune Epitope Database (IEDB) Analysis Resource was used to predict the binding affinity of human class I HLAs for epitope P1519 from NV genogroups I and II. The table lists HLAs that returned a percentile rank of <1.5. NA, not applicable.