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Hypothetical model of KDM3A and LANA interactions. During latency, the recruitment of KDM3A through LANA interactions maintains a euchromatin state (histones marked in red) on a subset of viral genes by preventing possession of the repressive H3K9me1/2 histone marks that form heterochromatin (histones marked in blue). Depletion of these repressive marks sets the stage for efficient lytic reactivation.
