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Summary of characteristics of wild type and mutants of AgQ1
| Protein | Reactivitya | Complex formation | CD46 binding |
|---|---|---|---|
| AgQ1 wild type | + | + | + |
| AgQ1(L494A) | + | + | ±b |
| AgQ1(C495A) | ±b | ±b | − |
| AgQ1(Q496A) | + | + | + |
| AgQ1(Q496E) | + | + | + |
| AgQ1(G497A) | + | + | + |
| AgQ1(Δ494-497) | − | − | − |
| AgQ1(494AAAA497) | − | − | − |
Reactivity to the Mab AgQ 1-1 in IFA (Fig. 3).
±, reactivity to the Mab AgQ 1-1 or interaction between each component seemed to be severely impaired, or binding to CD46 could hardly be detected.
