Table 5.
Associations With Relative Telomere Lengtha Involving Combinations of 25-Hydroxyvitamin D Level and Total Calcium Intake Categories, Nurses’ Health Study, 1989–1990
| Quartile of 25(OH)D Level | Calcium Intakeb | No. of Samples | ORc | 95% CIc | P Value |
|---|---|---|---|---|---|
| 1 | Low | 235 | 1.00 | Referent | |
| 2 | Low | 191 | 1.17 | 0.78, 1.75 | 0.46 |
| 3 | Low | 150 | 1.84 | 1.17, 2.90 | 0.009 |
| 4 | Low | 122 | 2.30 | 1.39, 3.81 | 0.001 |
| 1 | High | 144 | 1.33 | 0.86, 2.05 | 0.20 |
| 2 | High | 193 | 1.24 | 0.83, 1.87 | 0.30 |
| 3 | High | 184 | 1.30 | 0.85, 1.98 | 0.22 |
| 4 | High | 205 | 1.56 | 1.02, 2.41 | 0.04 |
Abbreviations: 25(OH)D, 25-hydroxyvitamin D; CI, confidence interval; OR, odds ratio.
a Telomere length was dichotomized at the median.
b Low: <1,000 mg/day; high: ≥1,000 mg/day.
c Adjusted for study batch, age in years (continuous), smoking status (0, 0.1–20, 20.1–40, or >40 pack-years), body mass index (weight (kg)/height (m)2) (<25, 25–29.9, 30–34.9, or ≥35), and physical activity level (nominal quartiles measured in metabolic equivalents per week).