Figure 2.

Siglec-6 expression does not change across preterm gestation in either control or PE groups. Siglec-6 expression levels were determined from immunoblots of placental tissue protein lysates (gestational age range 24-36 weeks, all from labored deliveries). Siglec-6 expression was normalized to actin expression to control for protein loading. Levels are reported as fold expression relative to a 25-week gestation sample run on all blots. Linear regression of Siglec-6 expression by gestational age showed no trend in either the basal plate (A) or chorionic villi (B) of preterm labor (n = 10, closed squares, solid line) or preterm PE samples (n = 11, open circles, dashed line). Basal plate: preterm labor, R ² = .20, P = .19, and preterm PE, R ² = .01, P = .74. Chorionic villi: preterm labor, R ² = .03, P = .61, and preterm PE, R ² = .16, P = .23. PE indicates preeclampsia; Siglec-6, sialic acid immunoglobulin–like lectin.