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. 2013 Apr;20(4):371–381. doi: 10.1177/1933719112459239

Figure 3.

Figure 3.

Ulipristal acetate (UPA) inhibits the expression of progesterone receptor (PR)-regulated genes during ovulation. Mice (n = 12) were subjected to superovulation as described in Materials and Methods section. Vehicle or UPA was administered intraperitoneally 2 hours after human chorionic gonadotropin (hCG) injection. Ovaries were collected at 11 hours after hCG injection and the total RNA was isolated. A, Real-time polymerase chain reaction (PCR) was performed to analyze the expression of PR-regulated genes, ET-2, ADAMTS-1, PPARγ, and Hif1α, in response to vehicle and UPA treatments. The level of Rplp0 was used as an internal control to normalize the gene expression. The values are presented as the mean fold induction ± standard error of the mean (SEM), *P < .01, **P < .001, and ***P < .0001. B, Real-time PCR was performed to analyze the expression of Ankrd1, Bdnf, Cnn3, Cyr61, Errfi1, Runx1, and Socs3, in response to vehicle and UPA treatments. The level of Rplp0 was used as an internal control to normalize gene expression. The values are presented as the mean fold induction ± standard error of the mean (SEM), *P < .01, **P < .001, and ***P < .0001.