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. Author manuscript; available in PMC: 2013 Jun 7.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2011 Dec 22;32(2):247–256. doi: 10.1161/ATVBAHA.111.240358

Figure 2.

Figure 2

Increased atherosclerotic lesion size in insulin receptor/insulin receptor substrate-1 double heterozygous apolipoprotein E (Insr+/−Irs1+/−Apoe−/−) mice. A, Representative en face Sudan IV staining of aortas from 23- to 25-week-old female Insr+/−Irs1+/−Apoe−/−, Insr+/+Irs1+/+Apoe−/− and Insr+/−Irs1+/− mice. Lesion sizes from the aortas of female (B) and male (C)Insr+/−Irs1+/−Apoe−/− and Insr+/+Irs1+/+Apoe−/− mice (% of whole aorta). Each symbol represents 1 animal, horizontal bars represent means. *P<0.05. (D) Representative Movat staining of brachiocephalic artery from 23- to 25-week-old male Insr+/−Irs1+/−Apoe−/− (left) and Insr+/+Irs1+/+Apoe−/− (right) mice. E, Cross-sectional lesion area from the sections of brachiocephalic arteries of Insr+/−Irs1+/−Apoe−/− and Insr+/+Irs1+/+Apoe−/− mice (n=5-8 mice for each group). *P<0.05.