Table. Body Weights, Total Cholesterol, Total Triglycerides, HDL and LDL Levels, and Blood Glucose in Insr^+/−Irs1^+/−Apoe^−/− and Insr^+/+Irs1^+/+Apoe^−/− Mice.

	Insr+/−Irs1+/−Apoe−/− (Female)	Insr+/−Irs1+/−Apoe−/− (Female)	Insr+/−Irs1+/−Apoe−/− (Male)	Insr+/−Irs1+/−Apoe−/− (Male)
Body weight (23 wks of age), g	22.9±0.4	23.7±0.5	30.4±1.0	32.9±1.2
Body weight (8 wks of age), g	16.2±0.6*	18.0±0.3	21.3±1.0	23.8±0.7
Total cholesterol, mg/dl	925±75	1166±106	1191 ±201	1032±199
Total triglycerides, mg/ml	94±8	122±29	129±16	153±26
HDL	41±15	55±16	35±11	47±12
VLDL	887±83	1092±97	1067±216	961 ±198
Fed glucose, mg/dl	223±27	176±17	199±21	156±10
Fasting glucose, mg/dl	99.5±12	122±13	129±14	120±21

Data are presented as mean±SE for n=7–17 mice. Mice were fed with a Western diet for 15 wk and plasma of fasted 23 wk old female and male mice were analyzed for total cholesterol, triglycerides, HDL, VLDL, and glucose levels

^*P<0.05.

Insr indicates insulin receptor; Irs1, insulin receptor substrate-1; Apoe, apolipoprotein.