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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Nat Med. 2012 Sep 9;18(10):1575–1579. doi: 10.1038/nm.2897

Figure 4.

Figure 4

Sln−/− mice are prone to develop obesity when fed HFD. (a) Increase in body weight during 12 weeks of HFD feeding (n = 8 mice per group). (b) Sln−/− mice fed HFD become obese compared to WT mice. (c) MRI of the fat distribution in representative mice fed on HFD. (d) Determination of the fat content of the mice in a. WAT, white adipose tissue. (e) Representative histological sections of intraperitoneal WAT, BAT and liver stained with H&E and osmium tetroxide (osmium tet) (seen as black dots). Scale bar, 25 μm. (f) Representative western blots of soleus and diaphragm muscle from chow-fed and HFD-fed WT and Sln−/− mice. n = 4. (g) Glucose tolerance test. *P < 0.05, **P < 0.01 for the comparison of WT and Sln−/− HFD-fed mice by one-way ANOVA. All data are means ± s.e.m.