Table 2. Treatment characteristics.
Category | Subcategory | All patients (n = 71) | RT alone (n = 51) | ChemoRT (n = 20) | p value |
Radiation therapy given | Brachytherapy alone | 9 (13%) | 9 (18%) | 0 (0%) | 0.006 |
EBRT alone | 10 (14%) | 10 (20%) | 0 (0%) | ||
EBRT+brachytherapy | 52 (73%) | 32 (63%) | 20 (100%) | ||
RT dose to Vagina (EQD2) | All RT groups | 68.2±15.4 Gy | 65.1±16.8 Gy | 76.0±6.5 Gy | 0.99 |
Brachy alone group | 54.2±22.2 Gy | 54.2±22.2 Gy | – | – | |
EBRT alone group | 48.4±7.1 Gy | 48.4±7.1 Gy | – | – | |
EBRT+brachy group | 74.4±9.3 Gy | 73.5±10.7 Gy | 76.0±6.5 Gy | 0.90 | |
EBRT fields | 4-field | 25 (35%) | 18 (35%) | 7 (35%) | 0.654 |
AP/PA | 32 (45%) | 21 (41%) | 11 (55%) | ||
Opposed laterals | 1 (1%) | 1 (2%) | 0 (0%) | ||
3-field | 1 (1%) | 0 (0%) | 1 (5%) | ||
En face | 1 (1%) | 1 (2%) | 0 (0%) | ||
Unknown | 2 (3%) | 1 (2%) | 1 (5%) | ||
Brachytherapy type | Cylinder | 26 (37%) | 21 (41%) | 5 (25%) | 0.235 |
Interstitial | 26 (37%) | 16 (31%) | 10 (50%) | ||
Tandem and ovoid | 4 (6%) | 1 (2%) | 3 (15%) | ||
Cylinder and tandem | 2 (3%) | 1 (2%) | 1 (5%) | ||
Interstitial and tandem | 2 (3%) | 1 (2%) | 1 (5%) | ||
Sutures | 1 (1%) | 1 (2%) | 0 (0%) | ||
Brachytherapy dose rate | HDR | 23 (32%) | 12 (24%) | 11 (55%) | 0.090 |
LDR | 38 (54%) | 29 (57%) | 9 (45%) | ||
Concurrent Chemotherapy | Yes | 20 (28%) | – | – | – |
Cisplatin | 17 (24%) | – | 17 (85%) | ||
Carboplatin | 2 (3%) | – | 2 (10%) | ||
5-FU | 1 (1%) | – | 1 (5%) | ||
Unknown | 0 (1%) | – | 0 (0%) | ||
Number of cycles chemo | ChemoRT group | 5 (1–8) | – | 5 (1–8) | – |
Surgery | Yes | 20 (28%) | 18 (35%) | 2 (10%) | 0.040 |
Wide excision | 7 (10%) | 6 (12%) | 1 (5%) | ||
Vaginectomy | 11 (16%) | 10 (20%) | 1 (5%) | ||
Pelvic exenteration | 2 (3%) | 2 (4%) | 0 (0%) |
Key: CRT, concurrent chemoradiation; EBRT, external-beam radiation therapy; EQD2, Equivalent dose in 2Gy fractions; AP/PA, anterioposterior/posterioanterior; HDR, high-dose-rate; LDR, low-dose-rate.