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. 2013 Jun 7;8(6):e65048. doi: 10.1371/journal.pone.0065048

Table 2. Treatment characteristics.

Category Subcategory All patients (n = 71) RT alone (n = 51) ChemoRT (n = 20) p value
Radiation therapy given Brachytherapy alone 9 (13%) 9 (18%) 0 (0%) 0.006
EBRT alone 10 (14%) 10 (20%) 0 (0%)
EBRT+brachytherapy 52 (73%) 32 (63%) 20 (100%)
RT dose to Vagina (EQD2) All RT groups 68.2±15.4 Gy 65.1±16.8 Gy 76.0±6.5 Gy 0.99
Brachy alone group 54.2±22.2 Gy 54.2±22.2 Gy
EBRT alone group 48.4±7.1 Gy 48.4±7.1 Gy
EBRT+brachy group 74.4±9.3 Gy 73.5±10.7 Gy 76.0±6.5 Gy 0.90
EBRT fields 4-field 25 (35%) 18 (35%) 7 (35%) 0.654
AP/PA 32 (45%) 21 (41%) 11 (55%)
Opposed laterals 1 (1%) 1 (2%) 0 (0%)
3-field 1 (1%) 0 (0%) 1 (5%)
En face 1 (1%) 1 (2%) 0 (0%)
Unknown 2 (3%) 1 (2%) 1 (5%)
Brachytherapy type Cylinder 26 (37%) 21 (41%) 5 (25%) 0.235
Interstitial 26 (37%) 16 (31%) 10 (50%)
Tandem and ovoid 4 (6%) 1 (2%) 3 (15%)
Cylinder and tandem 2 (3%) 1 (2%) 1 (5%)
Interstitial and tandem 2 (3%) 1 (2%) 1 (5%)
Sutures 1 (1%) 1 (2%) 0 (0%)
Brachytherapy dose rate HDR 23 (32%) 12 (24%) 11 (55%) 0.090
LDR 38 (54%) 29 (57%) 9 (45%)
Concurrent Chemotherapy Yes 20 (28%)
Cisplatin 17 (24%) 17 (85%)
Carboplatin 2 (3%) 2 (10%)
5-FU 1 (1%) 1 (5%)
Unknown 0 (1%) 0 (0%)
Number of cycles chemo ChemoRT group 5 (1–8) 5 (1–8)
Surgery Yes 20 (28%) 18 (35%) 2 (10%) 0.040
Wide excision 7 (10%) 6 (12%) 1 (5%)
Vaginectomy 11 (16%) 10 (20%) 1 (5%)
Pelvic exenteration 2 (3%) 2 (4%) 0 (0%)

Key: CRT, concurrent chemoradiation; EBRT, external-beam radiation therapy; EQD2, Equivalent dose in 2Gy fractions; AP/PA, anterioposterior/posterioanterior; HDR, high-dose-rate; LDR, low-dose-rate.