Table 3. Cox proportional hazards analyses.
Univariate | Disease-Free Survival | Overall Survival | ||
Variable | Crude HR (95% CI) | P value (Wald) | Crude HR (95% CI) | P value (Wald) |
Date of diagnosis (year) | 0.96 (0.93–0.99) | 0.011 | 0.96 (0.93–0.99) | 0.030 |
Chemotherapy | 0.28 (0.10–0.80) | 0.017 | 0.30 (0.09–0.99) | 0.049 |
FIGO stage | 1.53 (1.08–2.16) | 0.017 | 1.38 (0.95–2.00) | 0.096 |
Tumor size >4 cm | 2.12 (1.04–4.35) | 0.040 | 1.84 (0.83–4.06) | 0.131 |
Treatment duration (days) | 0.99 (0.97–1.001) | 0.072 | 0.98 (0.97–1.001) | 0.062 |
3D Diagnostic imaging | 0.54 (0.28–1.07) | 0.077 | 0.67 (0.31–1.42) | 0.295 |
Brachytherapy (any) | 0.50 (0.22–1.10) | 0.084 | 0.42 (0.18–0.97) | 0.041 |
RT dose to vagina (>70 Gy EQD2) | 0.55 (0.27–1.09) | 0.085 | 0.34 (0.15–0.77) | 0.009 |
Age at diagnosis | 1.02 (0.99–1.04) | 0.096 | 1.02 (0.999–1.04) | 0.066 |
Prior hysterectomy | 1.80 (0.89–3.62) | 0.100 | 1.71 (0.81–3.60) | 0.156 |
Tumor differentiation | 0.71 (0.45–1.11) | 0.130 | 0.65 (0.39–1.11) | 0.107 |
EBRT and brachytherapy | 0.59 (0.30–1.18) | 0.138 | 0.44 (0.20–0.94) | 0.034 |
Lymph node involvement | 0.90 (0.35–2.32) | 0.822 | 0.86 (0.30–2.49) | 0.781 |
Surgery | 0.99 (0.49–2.00) | 0.980 | 0.93 (0.42–2.07) | 0.866 |
Key: HR, hazard ratio; FIGO, Federation Internationale de Gynecologie et Obstetrique; EQD2, Equivalent dose in 2Gy fractions; EBRT, external-beam radiation therapy.