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. 2013 Jun 7;8(6):e65048. doi: 10.1371/journal.pone.0065048

Table 3. Cox proportional hazards analyses.

Univariate Disease-Free Survival Overall Survival
Variable Crude HR (95% CI) P value (Wald) Crude HR (95% CI) P value (Wald)
Date of diagnosis (year) 0.96 (0.93–0.99) 0.011 0.96 (0.93–0.99) 0.030
Chemotherapy 0.28 (0.10–0.80) 0.017 0.30 (0.09–0.99) 0.049
FIGO stage 1.53 (1.08–2.16) 0.017 1.38 (0.95–2.00) 0.096
Tumor size >4 cm 2.12 (1.04–4.35) 0.040 1.84 (0.83–4.06) 0.131
Treatment duration (days) 0.99 (0.97–1.001) 0.072 0.98 (0.97–1.001) 0.062
3D Diagnostic imaging 0.54 (0.28–1.07) 0.077 0.67 (0.31–1.42) 0.295
Brachytherapy (any) 0.50 (0.22–1.10) 0.084 0.42 (0.18–0.97) 0.041
RT dose to vagina (>70 Gy EQD2) 0.55 (0.27–1.09) 0.085 0.34 (0.15–0.77) 0.009
Age at diagnosis 1.02 (0.99–1.04) 0.096 1.02 (0.999–1.04) 0.066
Prior hysterectomy 1.80 (0.89–3.62) 0.100 1.71 (0.81–3.60) 0.156
Tumor differentiation 0.71 (0.45–1.11) 0.130 0.65 (0.39–1.11) 0.107
EBRT and brachytherapy 0.59 (0.30–1.18) 0.138 0.44 (0.20–0.94) 0.034
Lymph node involvement 0.90 (0.35–2.32) 0.822 0.86 (0.30–2.49) 0.781
Surgery 0.99 (0.49–2.00) 0.980 0.93 (0.42–2.07) 0.866

Key: HR, hazard ratio; FIGO, Federation Internationale de Gynecologie et Obstetrique; EQD2, Equivalent dose in 2Gy fractions; EBRT, external-beam radiation therapy.