Table 2.

Values of nRoA and nBias_avg for the 20 features with nRoA ≤ 20% for at least one of the three methods.

	Follow-up32×32		Resampled32×32		Affine32×32		Demons32×32
	nRoA (%)	nBiasavg (%)	nRoA (%)	nBiasavg (%)	nRoA (%)	nBiasavg (%)	nRoA (%)	nBiasavg (%)
First-order features
Minimum	5.82	−0.02	7.77	1.35	8.09	1.57	9.79	3.39
Mean	13.79	0.00	13.56	0.03	12.94	−0.02	7.58	0.24
Median	10.95	−0.03	10.83	0.13	10.74	0.14	7.30	0.19
Binned entropy	16.79	0.01	16.96	−1.20	16.15	−1.43	14.42	−4.03
Unbinned entropy	11.53	0.01	12.00	−1.66	11.52	−2.02	10.13	−4.66
5% quantile	10.11	−0.05	11.32	2.93	10.86	3.26	10.84	4.83
30% quantile	9.67	−0.04	9.65	1.15	9.56	1.28	7.46	1.85
70% quantile	16.77	−0.01	16.45	−0.82	15.88	−0.92	9.19	−1.45
Fractal features
Box counting dim.	15.13	−0.05	15.65	−3.92	13.53	−4.29	11.51	−5.91
Fine dimension	17.33	−0.04	21.03	−6.58	19.16	−7.08	16.27	−8.46
Brownian dimension	7.16	−0.01	6.85	−0.83	5.70	−0.91	4.48	−1.28
Laws’ filter features
E5L5 entropy	17.21	0.06	16.79	−1.46	14.05	−1.76	10.68	−2.54
R5L5 entropy	19.00	0.01	19.82	−5.23	17.66	−5.75	14.17	−4.01
S5L5 entropy	19.22	0.07	18.57	−2.67	15.65	−3.12	11.52	−3.67
W5L5 entropy	19.11	0.05	18.87	−4.04	16.31	−4.55	12.45	−4.36
GLCM features
Difference entropy	13.26	0.02	15.20	−4.93	13.54	−5.53	12.84	−9.48
Entropy	3.55	0.00	2.88	0.02	2.88	−0.03	3.04	−0.50
Sum of squares var.	15.48	0.03	15.75	−1.77	14.59	−2.12	12.94	−3.95
Sum average	7.12	0.01	7.32	−0.78	6.91	−0.94	6.36	−1.86
Sum entropy	8.38	0.01	8.78	−1.68	8.34	−1.94	7.23	−3.63
Mean across all features	12.87	0.00	13.30	−1.60	12.20	−1.81	10.01	−2.46