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. 2013 Jun 7;8(6):e65422. doi: 10.1371/journal.pone.0065422

Figure 4. Microinfusion of ghrelin into the LA interferes with the CTA memory acquisition, but has no effect on memory consolidation.

Figure 4

A, Illustrating of ghrelin’s effect on CTA acquisition.Top, schematic of the experimental design. Bottom, intra-LA infusion of ghrelin (12 ng, 0.75 µl per side) before training impairs acquisition of CTA, represented by significant smaller AI tested at 24 h after conditioning, compared to the vehicle group. B, Showing that the two groups of animals intakes similar amount of LiCl during conditioning. C, Showing that the two groups of animals consumes similar amount of liquid during tests. n = 20 for each group. D, Comparison of ghrelin’s effect on CTA memory consolidation versus acquisition.Top, schematic of the experimental design. Same dose of ghrelin was infused with reduced volume compared to that applied in A. Bottom, intra-LA infusion of ghrelin (12 ng, 0.5 µl per side) shortly after conditioning has no effect on CTA memory. n = 9–10 for each group. *p<0.05 and **p<0.01 means significant. Error bars indicate SEM.