Table 2.

Single-dose sitagliptin pharmacokinetics in the presence and absence of atorvastatin by ABCB1 diplotype group

Pharmacokinetic parameter	Sitagliptin Alone Arithmetic Mean ± SD	Sitagliptin + Atorvastatin Arithmetic Mean ± SD	Mean relative change (95% CI)	P Value (within diplotype groups)
Cmax (ng/ml)
ABCB1 CGC/CGC	454 ± 180	428 ± 201	0.96 (0.75-1.17)	0.43
ABCB1 CGC/TTT	438 ± 152	420 ± 137	1.0 (0.79-1.21)	0.69
ABCB1 TTT/TTT	394 ± 160	370 ± 217	0.93 (0.76-1.11)	0.26
P value, between diplotype groups	0.67	0.56	0.86
AUC0-∞ (ng*h/ml)
ABCB1 CGC/CGC	3638 ± 1439	3501 ± 1617	0.96 (0.81-1.11)	0.41
ABCB1 CGC/TTT	3502 ± 1133	3430 ± 1279	0.98 (0.88-1.07)	0.43
ABCB1 TTT/TTT	3129 ± 795	3117 ± 1216	0.97 (0.87-1.08)	0.45
P value, between diplotype groups	0.83	0.90	0.97
AUC0-24 (ng*h/ml)
ABCB1 CGC/CGC	3227 ± 1216	3205 ± 1420	0.99 (0.83-1.15)	0.66
ABCB1 CGC/TTT	3081 ± 925	3073 ± 1101	0.99 (0.89-1.09)	0.69
ABCB1 TTT/TTT	2809 ± 820	2799 ±1195	0.98 (0.92-1.04)	0.42
P value, between diplotype groups	0.80	0.82	0.97
CLRa (ml/min)
ABCB1 CGC/CGC	254 ± 176	280 ± 124	1.22 (0.97-1.48)	0.11
ABCB1 CGC/TTT	232 ± 62	226 ± 66	0.99 (0.82-1.16)	0.67
ABCB1 TTT/TTT	359 ± 182	339 ± 188	1.0 (0.81-1.18)	0.68
P value, between diplotype groups	0.21	0.22	0.14
fea
ABCB1 CGC/CGC	0.50 ± 0.09	0.55 ± 0.08	1.14 (0.89-1.39)	0.25
ABCB1 CGC/TTT	0.50 ± 0.06	0.47 ± 0.10	0.96 (0.81-1.11)	0.44
ABCB1 TTT/TTT	0.62 ± 0.22	0.56 ± 0.16	0.96 (0.78-1.14)	0.41
P value, between diplotype groups	0.44	0.36	0.24
t1/2 (h)
ABCB1 CGC/CGC	7.3 ± 3.0	6.2 ± 1.5	0.94 (0.70-1.17)	0.26
ABCB1 CGC/TTT	7.7 ± 2.5	7.3 ± 2.4	0.98 (0.78-1.17)	0.51
ABCB1 TTT/TTT	7.3 ± 2.3	7.4 ± 1.9	1.04 (0.90-1.17)	0.65
P value, between diplotype groups	0.82	0.16	0.49

^af_e and CL_R could not be calculated for three subjects (n=2, CGC/CGC; n=1, CGC/TTT). Data are expressed as arithmetic mean ± standard deviation or mean relative change (95% CI). Relative change=(sitagliptin + atorvastatin)/sitagliptin alone.

ABCB1 CGC/CGC, n=9; ABCB1 CGC/TTT, n=10; ABCB1 TTT/TTT, n=10.