Skip to main content
. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Eur J Clin Pharmacol. 2013 Feb 14;69(7):1401–1409. doi: 10.1007/s00228-013-1475-y

Table 3.

Single-dose sitagliptin pharmacokinetics in the absence and presence of atorvastatin (n=29)

Pharmacokinetic
parameter		 Sitagliptin
Geometric Mean
(90% CI)		 Sitagliptin +
Atorvastatin
Geometric Mean
(90% CI)		 GMR
(90% CI)		 P value
Cmax (ng/ml) 399 (352, 451) 371 (326, 424) 0.93 (0.86, 1.01) 0.16
AUC0-∞ (ng*h/ml) 3218 (2865, 3614) 3082 (2696, 3522) 0.96 (0.91, 1.01) 0.15
CLRa (ml/min) 254 (215, 300) 259 (225, 298) 1.02 (0.93, 1.12) 0.69
fea 0.52 (0.47, 0.58) 0.51 (0.47, 0.56) 0.98 (0.90, 1.06) 0.68
t1/2 (h)b 7.4 ± 2.5 7.0 ± 2.0 - 0.39
a

CLR and fe could not be calculated for three subjects due to missing urine samples or incomplete urine collection

b

arithmetic mean ± standard deviation. GMR=geometric mean ratio; CI=confidence interval.