TABLE 3.
Distances between engineered Cys based on the X-ray GluCl and NMR nAChR structure.s
| Y277 | M278 | L279 | F280 | T281 | M282 | V283 | |
|---|---|---|---|---|---|---|---|
| GluCl 3RHW | 12.5 | 8.7 | 9.8 | 12.2 | 10.3 | 8.1 | 11.7 |
| Torpedo 2BG9 (A) | 20.4 | 17.5 | 17.5 | 16.8 | 13.3 | 13.6 | 14.2 |
| nAChR α4 2LLY | 14.3 | 10.6 | 12.5 | 15.1 | 13.0 | 11.0 | 14.5 |
| nAChR β2 2LM2 | 13.3 | 10.8 | 13.8 | 14.8 | 11.4 | 11.3 | 14.9 |
| nAChR α1 WSA 2LKG | 12.5 | 8.9 | 10.6 | 13.5 | 12.6 | 11.0 | 14.5 |
| nAChR α1 WSA 2LKH | 12.0 | 8.3 | 9.4 | 12.6 | 11.8 | 10.5 | 13.8 |
Distances (Å) measured between the α-carbons of M2 T254 and M3 positions, or homologous residues, as indicated.