Figure 5.
Collapsin response mediator protein-2 (CRMP-2) breakdown following severe controlled cortical impact injury in wildtype (WT) and Prp-hCAST transgenic (Tg) mice. Quantification of a 55 kDa CRMP-2 fragment in A) cortical and B) hippocampal homogenates of WT and Prp-hCAST mice at 6 and 24 h after injury. Breakdown product (BDP) optical densities are represented as mean + SEM; **p<0.005 vs. sham and #p<0.05, ##p<0.005 vs. WT. Representative blots with GAPDH loading control are shown to the right. Full-length CRMP-2 bands (bracketed) appear overexposed in representative immunoblot images in order to identify the CRMP-2 BDP.