Table 3.
Smoking Status, Genetic Variation in GGT1, and Risk of Chronic Pancreatitis
| Smoking Status | ||||
|---|---|---|---|---|
|
| ||||
| Never Smokers | Ever Smokers | |||
|
| ||||
| SNP -Genotype | Cases/Controls | OR (95% CI)a | Cases/Controls | OR (95% CI)a |
|
| ||||
| rs8135987 | ||||
| TT | 51/106 | 1.0 (ref.) | 146/109 | 3.07 (1.98-4.76) |
| CT or CC | 78/122 | 1.35 (0.86-2.13) | 212/115 | 4.14 (2.70-6.34) |
|
| ||||
|
Pinteraction =0.73
| ||||
| rs4820599 | ||||
| AA | 55/107 | 1.0 (ref.) | 163/124 | 2.80 (183-4.29) |
| AG or GG | 76/123 | 1.23 (0.78-1.92) | 198/103 | 4.07 (2.65-6.25) |
|
| ||||
|
Pinteraction =0.12
| ||||
| rs5751901 | ||||
| TT | 47/94 | 1.0 (ref.) | 142/100 | 3.18 (2.00-5.05) |
| CT or CC | 83/136 | 1.26 (0.80-2.00) | 218/124 | 3.89 (2.51-6.03) |
|
| ||||
|
Pinteraction =0.58
| ||||
| rs2017869 | ||||
| GG | 42/80 | 1.0 (ref.) | 130/95 | 2.78 (1.72-4.49) |
| CG or CC | 89/158 | 1.08 (0.67-1.74) | 232/132 | 3.52 (2.24-5.53) |
|
| ||||
| Pinteraction =0.22 | ||||
a
Adjusted for age (continuous), sex (male, female), race (white, other) and alcohol use (never, ever)