Table 4.
Alcohol Use, Genetic Variation in GGT1, and Risk of Chronic Pancreatitis
| Alcohol Use
|
||||||
|---|---|---|---|---|---|---|
| Never | Ever | Very Heavy | ||||
|
| ||||||
| SNP – Genotype | Cases/Controls | OR (95% CI)a | Cases/Controls | OR (95% CI)a | Cases/Controls | OR (95% CI)a |
|
| ||||||
| rs8135987 | ||||||
| TT | 35/50 | 1.0 (ref.) | 160/163 | 0.80 (0.47-1.37) | 49/8 | 3.54 (1.31-9.61) |
| CT or CC | 67/72 | 1.49 (0.84-2.65) | 224/168 | 1.06 (0.63-1.78) | 77/18 | 2.20 (0.94-5.14) |
|
| ||||||
|
Pinteraction =0.82
| ||||||
| rs4820599 | ||||||
| AA | 46/51 | 1.0 (ref.) | 169/178 | 0.60 (0.36-0.98) | 57/13 | 1.99 (0.84-4.74) |
| AG or GG | 59/74 | 1.03 (0.59-1.81) | 217/155 | 0.91 (0.56-1.49) | 69/13 | 2.20 (0.92-5.24) |
|
| ||||||
|
Pinteraction =0.44
| ||||||
| rs5751901 | ||||||
| TT | 34/44 | 1.0 (ref.) | 153/146 | 0.76 (0.44-1.31) | 49/9 | 2.41 (0.90-6.48) |
| CT or CC | 70/79 | 1.28 (0.72-2.29) | 232/186 | 0.91 (0.54-1.55) | 78/17 | 2.23 (0.97-5.13) |
|
| ||||||
|
Pinteraction =0.54
| ||||||
| rs2017869 | ||||||
| GG | 30/36 | 1.0 (ref.) | 140/136 | 0.67 (0.38-1.21) | 43/8 | 2.31 (0.82-6.50) |
| CG or CC | 75/89 | 1.08 (0.59-1.98) | 247/198 | 0.84 (0.48-1.47) | 84/18 | 2.08 (0.89-4.90) |
|
| ||||||
| Pinteraction = 0.94 | ||||||
a
Adjusted for age (continuous), sex (male, female), race (white, other) and smoking status (never, former, current)