Skip to main content
. Author manuscript; available in PMC: 2014 Feb 28.
Published in final edited form as: J Med Chem. 2013 Feb 18;56(4):1693–1703. doi: 10.1021/jm301774u

Scheme 5. Synthesis of Compound 89a.

Scheme 5

aReagents and conditions: (a) 4-bromopyridine, Pd(PPh3)4, Na2CO3 (2.0 M), THF, 65 °C; (b) MeI, acetone; (c) NaBH4, EtOH; (d) 10% KOH (H2O)/EtOH (1:1); (e) 2-(2,3-dihydrobenzofuran-5-yl)ethanol, EDCI, DMAP, CH2Cl2.