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. 2013 Jun 7;8(6):e65330. doi: 10.1371/journal.pone.0065330

Figure 6. Hypothetical model for E6AP mediated negative regulation of adipogenesis.

Figure 6

Depicts a hypothetical model suggesting higher expression of the E3 ubiquitin ligase E6AP in preadipocytes inhibits proadipogenic transcription factor C/EBPα apparently by targeting it for ubiquitin mediated degradation and thereby attenuating its transactivation potential and adipocyte differentiation.