Table 1.

Behavioral performance of MCAT and WT mice in the rotorod, open field, elevated zero maze, fear conditioning, and novel object recognition tests.

	Rotarod			Open Field
	Fall Latency (s)			Time in Center (s)
	Session 1	Session 2	Session 3	Session 1	Session 2	Session 3	Session 4
WT	33.79 ± 2.83	41.74 ± 3.93	46.92 ± 4.11	145.32 ± 19.75	150.36 ± 16.29	130.16 ± 25.20	109.87 ± 24.08
MCAT	37.49 ± 4.33	42.83 ± 4.39	54.52 ± 5.41	120.42 ± 14.57	124.88 ± 10.79	69.11 ± 7.42	80.27 ± 11.48
	Zeromaze			Distance Moved (cm)
	Velocity (cm/s)	Crossings*	% Time in Open*	Session 1	Session 2	Session 3	Session 4
WT	4.46 ± 0.15	29.56 ± 3.92	7.62 ± 1.08	6447.80 ± 429.98	4867.29 ± 271.37	3865.7415 ± 285.79	3763.43 ± 249.96
MCAT	4.47 ± 0.09	39.89 ± 3.39	14.40 ± 1.61	7186.97 ± 224.72	5284.29 ± 241.16	4374.05 ± 211.68	3199.96 ± 249.94
	Fear Conditioning			Border Crossings
	Training			Session 1	Session 2	Session 3	Session 4
	Tone 3	Tone 4	Tone 5
WT	6.02 ± 4.37	13.19 ± 8.87	13.75 ± 4.98	70.44 ± 6.24	65.89 ± 4.20	37.00 ±4.13	33.00 ±4.72
MCAT	10.60 ± 6.02	10.09 ± 5.91	27.18 ± 0.69	75.00 ±8.12	61.22 ±4.90	38.56 ±4.88	33.11 ±4.41
				Novel Object
	% Baseline Freezing	% Context Freezing*	%Cued Freezing	Exploration Time (Old + Novel) (seconds)		Time Exploring Novel Object (%)
WT	0.99 ± 0.87	4.61 ± 1.44	22.02 ± 6.89	77.17 ± 11.40		61.34 ± 3.04
MCAT	0.10 ± 0.10	10.24 ± 1.68	31.08 ± 4.47	56.86 ± 5.68		56.16 ± 3.06