Table 1.
Mean, standard deviation and p values of cognitive tests in individuals with cystinosis treated before or after age 2 years.
| Cognitive Measure | Controls | Early-Treatment | Late-Treatment | P value* |
|---|---|---|---|---|
| Verbal IQ | 114.0 ± 14.8 n = 85 |
98.2 ± 11.1 n = 32 |
88.6 ± 15.2 n = 14 |
.022 |
| Performance IQ | 110.8 ± 13.2 n = 85 |
92.7 ± 15.3 n = 32 |
81.6 ±13.2 n = 14 |
.023 |
| Full Scale IQ | 113.6 ± 13.2 n = 85 |
94.0 ± 12.5 n = 32 |
83.0 ± 15.1 n = 14 |
.013 |
| Spatial Relations | 104.7 ± 16.1 n = 81 |
104.5 ± 12.0 n = 29 |
92.7 ± 22.6 n = 11 |
.038 |
| Visual Motor (VMI) | 97.1 ± 13.2 N = 81 |
88.5 ± 17.5 n = 30 |
82.3 ± 13.1 n = 11 |
NS |
| Picture Completion | 11.43 ± 2.92 n = 75 |
9.04 ± 3.49 n = 27 |
7.18 ± 3.43 n = 11 |
.144 |
| Block Design | 12.45 ± 3.26 n = 82 |
8.88 ± 2.91 n = 33 |
6.71 ± 3.56 n = 14 |
.035 |
| Symbol Search | 12.33 ± 2.88 n = 75 |
7.85 ± 2.64 n = 27 |
7.09 ± 2.39 n = 11 |
.414 |
*
Statistical comparisons of Early- vs. Late-Treatment groups.
p values for cystinosis groups compared with controls were all <.001.