Table 3.
AlphaScreen IC50 values and KD values for A-ring analogs (values in µM).
| # | Alpha | ITC KD | # | Alpha | ITC KD |
|---|---|---|---|---|---|
| 35 | ND | 4.3 | 47 | > 30 | ~6 |
| 37 | >10 | >20 | 48 | NA | – |
| 39 | >5 | – | 49 | NA | – |
| 41 | >2 | – | 50 | NA | – |
| 44 | ND | >10 | 54 | NA | 5 |
| 46 | NA | ~3 | 55 | NA | 5 |
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