Figure 1. Allometric scaling of NCA derived PK parameters for FVIII.

Linear regression was performed to fit an allometric equation to clearance (CL), steady state volume (Vss), mean residence time (MRT), and half-life (t_1/2). Each dot represents a separate PK study and studies with multiple doses or formulation are reflected as multiple dots. Solid black lines represent the lines of allometry and dashed red lines are the 95% prediction intervals. Square of the correlation coefficients and final scaling equations are shown.