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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: J Pharm Sci. 2013 Apr 25;102(7):2380–2394. doi: 10.1002/jps.23566

Figure 3. Relating PK profiles of FVIII across species.

Figure 3

Figure 3

Figure 3

(3a) Representative profiles for the PK of FVIII in different species normalized to a 50 IU/kg dose. Curves are shown for HA human (black), HA dog (red), normal rabbit (green), normal monkey (gold), and HA mouse (blue) profiles. (3b) Predictions of a 50 IU/kg dose of FVIII in humans based on the Dedrick plot method and segregated by predictive species. The solid line represents the expected HA human (black) profile as compared to predictions from HA dog (red), normal rabbit (green), normal monkey (gold), and HA mouse (blue). (3c) Normalized Wajima curves for FVIII across species. Mean parameters in each species were used to simulate concentration-time curves that were converted to normalized time (t′) and normalized concentrations (C′) based on the observed Css and MRT in each species. Normalized curves are shown in HA human (black), HA dog (red), normal rabbit (green), normal monkey (yellow), and HA mouse (blue).