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. Author manuscript; available in PMC: 2014 Jul 1.

Published in final edited form as: J Pharm Sci. 2013 Apr 25;102(7):2380–2394. doi: 10.1002/jps.23566

(4a) Observed concentrations following 25 (closed circles) and 65 (open circles) IU/kg doses of FVIII in humans in the study by Powell et al.²⁴ The Wajima method was used to generate predictions for the 25 (solid line) and 65 (dashed line) IU/kg doses using CL and Vss values predicted from the allometric relationships for a 70 kg individual. (4b) Observed concentrations for Fc FVIII given to HA mice (closed circles), normal mice (open circles), and HA dogs (closed triangles) following a 125 IU/kg dose.²⁴ Values are expressed as normalized time (t′) and normalized concentration (C′) based on the MRT and Css values observed for each treatment. The fitted regression line for Fc FVIII is shown (solid line) with the normalized Wajima curve for rFVIII (dotted line) as reference. (4c) Observed concentrations following 25 (closed circles) and 65 (open circles) IU/kg doses of Fc FVIII in humans.²⁴ The Wajima method was used to generate predictions for the 25 (solid line) and 65 (dashed line) IU/kg doses using allometrically derived CL and Vss values for a 70 kg individual and corrected for preclinical observations with the ‘informed scaling’ approach.

(4a) Observed concentrations following 25 (closed circles) and 65 (open circles) IU/kg doses of FVIII in humans in the study by Powell et al.²⁴ The Wajima method was used to generate predictions for the 25 (solid line) and 65 (dashed line) IU/kg doses using CL and Vss values predicted from the allometric relationships for a 70 kg individual. (4b) Observed concentrations for Fc FVIII given to HA mice (closed circles), normal mice (open circles), and HA dogs (closed triangles) following a 125 IU/kg dose.²⁴ Values are expressed as normalized time (t′) and normalized concentration (C′) based on the MRT and Css values observed for each treatment. The fitted regression line for Fc FVIII is shown (solid line) with the normalized Wajima curve for rFVIII (dotted line) as reference. (4c) Observed concentrations following 25 (closed circles) and 65 (open circles) IU/kg doses of Fc FVIII in humans.²⁴ The Wajima method was used to generate predictions for the 25 (solid line) and 65 (dashed line) IU/kg doses using allometrically derived CL and Vss values for a 70 kg individual and corrected for preclinical observations with the ‘informed scaling’ approach.