Table 2.
Summary of FVIII NCA parameters.
| Species | Disease Condition | N= | Dose (IU/kg) | BW (kg) | CL (mL/h) | Vss (mL) | MRT (h) | Half-life (h) |
|---|---|---|---|---|---|---|---|---|
| Human | HA | 80 | 44.9 (12.9) | 68.1 (12.5) | 231 (63) | 3950 (1040) | 18.1 (4.5) | 13.0 (2.0) |
| Mouse | HA | 19 | 152 (119) | 0.0225 | 0.312 (0.306) | 1.65 (0.65) | 7.3 (3.1) | 4.7 (2.1) |
| Dog | HA | 8 | 212 (178) | 17.3 (0.8) | 101 (33) | 1220 (360) | 12.1 (2.0) | 9.7 (2.3) |
| Mouse | Normal | 3 | 249 (139) | 0.0229 (0.0005) | 0.377 (0.254) | 2.13 (1.23) | 6.2 (1.3) | 4.6 (0.8) |
| Rat | Normal | 1 | 400. | 0.253 | 4.10 | 31.6 | 7.7 | 5.5 |
| Monkey | Normal | 2 | 209 | 4.00 | 26.7 | 298 | 12.2 | 9.0 |
| Rabbit | Normal | 1 | 100. | 4.50 | 38.3 | 336 | 8.8 | 6.7 |
Data presented as mean (standard deviation)