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Summary of FVIII two compartment parameters.
| Species | Disease Condition | N= | Dose (IU/kg) | BW (kg) | CL (mL/h) | V1 (mL) | CLd (mL/h) | V2 (mL) |
|---|---|---|---|---|---|---|---|---|
| Human | HA | 35 | 47.8 (10.6) | 70.2 (11.5) | 218 (44) | 3160 (590) | 178 (111) | 1070 (540) |
| Mouse | HA | 3 | 127 (133) | 0.0225 | 0.274 (0.029) | 1.30 (0.72) | 0.565 (0.373) | 0.777 (0.222) |
| Dog | HA | 4 | 111 (13) | 17.6 (1.1 | 96.7 (28.9) | 871 (245) | 47.4 (43.1) | 202 (63) |
| Monkey | Normal | 2 | 209 | 4.0 | 25.0 | 159 | 45.0 | 132 |
| Rabbit | Normal | 1 | 100 | 4.5 | 38.4 | 270 | 18.0 | 76.5 |
Data presented as mean (standard deviation)
