Table 1. Effect of Tat on cocaine-induced inhibition of [³H]DA uptake into rat striatal synaptosomes.

Data are presented as mean ± S.E.M. of three independent experiments performed in duplicate.

Drug	IC50 (nM)	Specific Uptake a (%)
Cocaine	510 ± 30	100
Cocaine + Indatraline (10 nM)	2000 ± 210*	33 ± 2.5
Cocaine + SoRI-20040 (12.8 μM)	715 ± 48*	30 ± 2.4
Cocaine + Tat (5 μM)	953 ± 70*	45 ± 3.1

^*P < 0.05 compared with the IC₅₀ value of cocaine (Student’s t test).

^aEach test agent reduced specific [³H]DA uptake and the degree of reduction is reported as a percentage of control.