Table 4.
Gene interaction networks and gene clusters
| official_gene_symbol | Gene name | Entrez_gene_ID | log2 (Fold-change) |
|---|---|---|---|
| Gene group 1 enrichment score: 8.84 | |||
| HOXB8 | Homeobox B8 | 3218 | 6.35 |
| HOXB7 | Homeobox B7 | 3217 | 6.25 |
| HOXB5 | Homeobox B5 | 3215 | 5.32 |
| HOXB3 | Homeobox B3 | 3213 | 2.76 |
| HOXB2 | Homeobox B2 | 3212 | 2.47 |
| HOXB6 | Homeobox B6 | 3216 | 2.16 |
| HOXA2 | Homeobox A2 | 3199 | 2.06 |
| HOXD4 | Homeobox D4 | 3233 | 1.96 |
| HOXD1 | Homeobox D1 | 3231 | 1.63 |
| HOXB4 | Homeobox B4 | 3214 | 1.61 |
| MEOX2 | Mesenchyme homeobox 2 | 4223 | 1.52 |
| TBX15 | T-box 15 | 6913 | −1.66 |
| BARX1 | BARX homeobox 1 | 56033 | −1.66 |
| DLX1 | Distal-less homeobox 1 | 1745 | −1.70 |
| PITX1 | Paired-like homeodomain 1 | 5307 | −1.80 |
| EMX2 | Empty spiracles homeobox 2 | 2018 | −2.03 |
| SHOX | Short stature homeobox | 6473 | −2.23 |
| HOXA11 | Homeobox A11 | 3207 | −2.88 |
| HOXA13 | Homeobox A13 | 3209 | −3.24 |
| HOXA10 | Homeobox A10 | 3206 | −5.06 |
| Gene group 2 enrichment score: 2.68 | |||
| WFDC3 | WAP four-disulfide core domain 3 | 140686 | 1.87 |
| PDGFRL | Platelet-derived growth factor receptor-like | 5157 | 1.81 |
| ANGPTL7 | Angiopoietin-like 7 | 10218 | −1.53 |
| LYPD6 | LY6/PLAUR domain containing 6 | 130574 | −2.10 |
| Gene group 3 enrichment score: 2.32 | |||
| FGFBP2 | Fibroblast growth factor binding protein 2 | 83888 | 1.91 |
| GDF15 | Growth differentiation factor 15 | 9518 | 1.77 |
| SFRP4 | Secreted frizzled-related protein 4 | 6424 | 1.54 |
| ANGPTL7 | Angiopoietin-like 7 | 10218 | −1.53 |
| Gene group 4 enrichment score: 1.20 | |||
| CNTNAP3B | Contactin associated protein-like 3B | 389734 | 2.38 |
| FAM134B | FAMILY WITH SEQUENCE SIMILARITY (134 MEMBER B) | 54463 | 2.30 |
| EVI2A | Ecotropic viral integration site 2A | 2123 | 2.18 |
| XG | Xg blood group | 7499 | 1.82 |
| F2RL2 | Coagulation factor II (thrombin) receptor-like 2 | 2151 | 1.65 |
| SHISA2 | Shisa homolog 2 (Xenopus laevis) | 387914 | 1.65 |
| SLC7A11 | Solute carrier family 7. member 11 | 23657 | 1.64 |
| IL18R1 | Interleukin 18 receptor 1 | 8809 | 1.53 |
| LRRN1 | leucine rich repeat neuronal 1 | 57633 | −1.52 |
| EFNB2 | Ephrin-B2 | 1948 | −1.54 |
| CDH6 | CADHERIN 6. TYPE 2. K-CADHERIN (FETAL KIDNEY) | 1004 | −1.65 |
| FAM162B | Family with sequence similarity (162 member B) | 221303 | −1.79 |
| TSPAN13 | TETRASPANIN 13 | 27075 | −1.80 |
| PCDH7 | Protocadherins (7) | 5099 | −1.83 |
| PCDH10 | Protocadherins (10) | 57575 | −2.01 |
| TM4SF20 | Transmembrane 4 L six family member 20 | 79853 | −2.04 |
| GPR116 | G protein-coupled receptor 116 | 221395 | −2.22 |
| GENE group 5 enrichment score: 0.39 | |||
| ZIC4 | Zinc finger protein. ZNF of the cerebellum 4 | 84107 | 4.26 |
| ZNF608 | Zinc finger protein. ZNF608 | 57507 | 2.41 |
| ZCCHC5 | Zinc finger protein with CCHC domain containing 5 | 203430 | 1.70 |
| ZBTB46 | Zinc finger protein with BTB domain containing 46 | 140685 | 1.65 |
The 46 genes that were clustered by the DAVID algorithm are listed in their five gene cluster groupings with gene enrichment scores, with associated fold-changes per gene. Gene cluster analysis of differentially regulated genes in primary human osteoblasts. Up-regulated genes are shown in red, Down-regulated genes are shown in green