Table 3.

Summary of studies evaluating rifampicin-loaded bone cement

Study	Cement type	Amount of antibiotics	Methods	Results	Conclusion
Anquita-Alonso et al. [1]	Simplex P (Stryker, Mahwah, NJ, USA)	2.5%/ 7.5%/ 15.0 %	Micrococcus luteus ATCC 9341	5 ± 2/147 ± 15/409 ± 46 ug/mL/hour of area under the curve, 4 ± 1/15 ± 2/31 ± 11 ug/mL of peak concentration	Rifampicin may be suitable for management of orthopaedic infections.
Beeching et al. [2]	CMW1 (Depuy, Blackpool, UK)	2.5 %	Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922	Not documented	Did not harden for several days.
De Palma et al. [13]	CMW (Depuy, Blackpool, UK)	1.2 g/40 g	Strength test	Not documented	The combination of rifampicin with CMW cement prevented complete polymerization of the cement.
Current study	CMW 3 (Depuy, Blackpool, UK)	Rifampicin 1 g/2 g/4 g	Compressive strength, antibacterial activity	Strength could not be measured; partially effective antibacterial activity	Polymerization was prevented.

ATCC = American Type Culture Collection.