Figure 2.

Excisional wound healing in Smad 3 KO mice. Smad3 KO mice display opposite wound-healing responses in the dorsal skin versus the ear as described in section Modulation of Smad expression. (a) Dorsal skin 48 h after wounding stained with hematoxylin/eosin. Arrows point to epithelial wound margins. Scale bar: 100 μm. (b) Ear wounds 38 days after wounding. (c) Ear wounds in SVEV129 mice at 36 days after wounding. The differences in ear wounds are more apparent in the pure SVEV129 strain as compared with the mixed strain (C57BL/6×Black Swiss×SVEV129) shown in (b). KO, knockout. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/wound