Figure 3.

Schematic diagram summarizing available information obtained using animal models to investigate the role of TGF-β signaling in wound healing. The basic components of the TGF-β signaling pathway shown in Figure 1 are used here as a background to illustrate the phenotypic differences observed from manipulating the specific components in wound-healing studies. See text sections Manipulation of TGF-β signaling in wound healing using exogenously added molecules and Genetic manipulation of TGF-β signaling in wound healing for a detailed account of the signaling components manipulated and the specific effects on the wound-healing outcome. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/wound