Table 2.

Results

Program Operating Characteristics	Liver Biopsy alone (1)	Fibrosure algorithm (2)	Difference (1–2)	Fibrospect II (3)	Difference (1–3)	Fibroscan (4)	Difference (1–4)
True postive (TP)	31%	26%	−5%	25%	−6%	21%	−10%
True negative (TN)	69%	60%	−9%	49%	−20%	61%	−8%
False postive (FP)	0%	9%	9%	20%	20%	8%	8%
False negative (FN)	0%	5%	5%	6%	6%	10%	10%
Program Sensitivity	100%	84%	−16%	81%	−19%	67%	−33%
Program Specificity	100%	87%	−13%	71%	−29%	89%	−11%
Program PPV	100%	74%	−26%	56%	−44%	73%	−27%
Program NPV	100%	92%	−8%	89%	−11%	86%	−14%
Number accurate diag (TP+TN)	100%	86%	−14%	74%	−26%	82%	−18%
Number incorrect diagnosis (FP+FN)	0%	14%	14%	26%	26%	18%	18%
Percent accurate diagnosis	100%	86%	−14%	74%	−26%	82%	−18%
Outcomes
Program cost per person	$1,255	$488	−$767	$350	−$905	$131	−$1,124
Cost of inappropriate drug spending* (millions)	$0	$1.7	−$1.7	$3.7	−$3.7	$1.4	−$1.4
Cost / accurate diagnosis	$1,255	$568	−$687	$471	−$784	$159	−$1,096

^*1 year treatment of false positive