Table 2.
Program Operating Characteristics |
Liver Biopsy alone (1) |
Fibrosure algorithm (2) |
Difference (1–2) |
Fibrospect II (3) |
Difference (1–3) |
Fibroscan (4) |
Difference (1–4) |
---|---|---|---|---|---|---|---|
True postive (TP) | 31% | 26% | −5% | 25% | −6% | 21% | −10% |
True negative (TN) | 69% | 60% | −9% | 49% | −20% | 61% | −8% |
False postive (FP) | 0% | 9% | 9% | 20% | 20% | 8% | 8% |
False negative (FN) | 0% | 5% | 5% | 6% | 6% | 10% | 10% |
Program Sensitivity | 100% | 84% | −16% | 81% | −19% | 67% | −33% |
Program Specificity | 100% | 87% | −13% | 71% | −29% | 89% | −11% |
Program PPV | 100% | 74% | −26% | 56% | −44% | 73% | −27% |
Program NPV | 100% | 92% | −8% | 89% | −11% | 86% | −14% |
Number accurate diag (TP+TN) | 100% | 86% | −14% | 74% | −26% | 82% | −18% |
Number incorrect diagnosis (FP+FN) | 0% | 14% | 14% | 26% | 26% | 18% | 18% |
Percent accurate diagnosis | 100% | 86% | −14% | 74% | −26% | 82% | −18% |
Outcomes | |||||||
Program cost per person | $1,255 | $488 | −$767 | $350 | −$905 | $131 | −$1,124 |
Cost of inappropriate drug spending* (millions) | $0 | $1.7 | −$1.7 | $3.7 | −$3.7 | $1.4 | −$1.4 |
Cost / accurate diagnosis | $1,255 | $568 | −$687 | $471 | −$784 | $159 | −$1,096 |
1 year treatment of false positive