Figure 1. Example of suspicious MRI findings in a patient with a large anterior tumor missed by systematic sampling but detected on the MRI-prompted biopsy.
A, Axial T2-weighted fast spin echo image of the mid-third of the prostate. Tumor is not clearly demonstrated with this sequence. B, Corresponding color-coded DCE 3D T1-weighted gradient-echo image. The large anterior tumor is easily seen as a cluster of bright red pixels (arrows) with an asymmetric distribution compared to the contralateral side. C, Whole-mount histopathology proven Gleason 4+3 cancer (area delineated by the dotted line). Note that whole-mounts were available in selected patients as part of a large clinical trial, but were not used as the gold-standard.


