Table 3.

Association between telomere length and weight change since age 50 among women older than 55 years, the Shanghai Women’s Health Study

Weight change since age 50	Relative Telomere Length
	N (%)	aMean (95%CIs)	P	bMean (95%CIs)	cRatio (95%CIs)	P
Weight change
Loss ≥5% weight since 50 years	154 (11.9)	0.905 (0.876, 0.935)	0.822	0.907 (0.877, 0.937)	0.989 (0.951, 1.027)	0.869
Gain/loss < ± 5% weight since 50 years	429 (33.1)	0.918 (0.900, 0.936)	-	0.917 (0.899, 0.935)	Ref. (1.00)	-
Gain 5–15% weight since 50 years	460 (35.5)	0.889 (0.872, 0.906)	0.053	0.889 (0.872, 0.906)	0.969 (0.942, 0.996)	0.055
Gain >15% weight since 50 years	252 (19.5)	0.883 (0.861, 0.906)	0.051	0.883 (0.861, 0.906)	0.963 (0.932, 0.994)	0.060
P for trend		0.029		0.025
Groups based on current BMI and BMI at age 50
Group 1 (Maintained a normal BMI)	501 (41.0)	0.911 (0.895, 0.928)	-	0.912 (0.896, 0.929)	Ref. (1.00)	-
Group 2 (Changed from obesity/overweight to normal BMI or from obesity to overweight )	81 (6.6)	0.914 (0.874, 0.957)	1.000	0.913 (0.872, 0.956)	1.001 (0.952, 1.051)	1.000
Group 3 (Changed from normal to overweight)	268 (21.9)	0.902 (0.880, 0.925)	0.974	0.903 (0.881, 0.926)	0.990 (0.959, 1.021)	0.944
Group 4 (Stayed within the overweight BMI range)	244 (20.0)	0.900 (0.877, 0.924)	0.898	0.899 (0.876, 0.923)	0.986 (0.954, 1.018)	0.872
Group 5 (Changed from normal/overweight to obesity or stayed within the obesity BMI range)	128 (10.5)	0.862 (0.832, 0.894)	0.032	0.860 (0.829, 0.892)	0.943 (0.904, 0.982)	0.023
P for trend		0.025		0.024

^aAdjusted for age and educational level.

^bMultiple adjustment for age, educational level, cigarette smoking status, regular alcohol consumption, cancer case/control status and comorbidities.

^cDerived from the results with multiple adjustment