Table 2.
Association between the -1327C>ThTERTgenotype and the risk of overall malignancy in autopsy cases
| Genotype distribution, n (%) | Risk for malignancya | Risk for multiple malignanciesb | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Controlc | Single malignancy cases | Multiple malignancy cases | Crude OR (95% CI) | p-value | Adjusted ORd (95% CI) | p-value | Crude OR (95% CI) | p-value | Adjusted ORd (95% CI) | p-value | |
| CC | 245 (41.5) | 308 (43.3) | 130 (52.2) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | ||||
| CT | 272 (46.0) | 324 (45.6) | 100 (40.2) | 0.87 | 0.22 | 0.86 | 0.22 | 0.69 | 0.021 | 0.68 | 0.024 |
| (0.70 - 1.08) | (0.68 - 1.09) | (0.51 - 0.95) | (0.548- 0.95) | ||||||||
| TT | 74 (12.5) | 79 (11.1) | 19 (7.6) | 0.74 | 0.085 | 0.68 | 0.041 | 0.48 | 0.0065 | 0.46 | 0.0046 |
| (0.53 - 1.04) | (0.48 - 0.98) | (0.27 - 0.82) | (0.25 - 0.79) | ||||||||
| Dominant model | |||||||||||
| CC | 245 (41.5) | 308 (43.3) | 130 (52.2) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | ||||
| CT + TT | 346 (58.5) | 403 (56.7) | 119 (47.8) | 0.84 | 0.11 | 0.82 | 0.087 | 0.65 | 0.0043 | 0.63 | 0.0040 |
| (0.69 - 1.04) | (0.66 - 1.03) | (0.48 - 0.87) | (0.45 - 0.86) | ||||||||
| Recessive model | |||||||||||
| CC + CT | 517 (87.5) | 632 (88.9) | 230 (92.4) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | ||||
| TT | 74 (12.5) | 79 (11.1) | 19 (7.6) | 0.79 | 0.16 | 0.73 | 0.080 | 0.58 | 0.033 | 0.55 | 0.024 |
| (0.58 - 1.10) | (0.53 - 1.04) | (0.33 - 0.96) | (0.31 - 0.93) | ||||||||
| Additive modele | 0.86 | 0.063 | 0.70 | 0.036 | 0.69 | 0.0017 | 0.67 | 0.0014 | |||
| (0.74 - 1.01) | (0.51 - 0.98) | (0.55 - 0.87) | (0.53 - 0.86) | ||||||||
The risk of malignancy was estimated by calculating crude OR and OR adjusted for age, sex, smoking status and alcohol habit using a logistic regression model in autopsy cases (n = 1551). Significant associations highlighted in bold.
OR odds ratio, CI confidence interval.
aCases with at least one malignancy were compared with control.
bCases with more than two malignancies were compared with control.
cCases with no malignancy (n = 591).
dCalculated for cases for whom smoking and drinking history was available (n = 1371).
eApplied by including the number of T-alleles (0,1,2) as a continuous variable in the logistic regression model.