Table 2.
Effects of intra-NAcbC infusions of the D3 receptor antagonist nafadotride (0.03 μg per side) combined with quinipirole on the 5-CSRTT (1 μg per side) in HI rats (n = 5) and LI rats (n = 4)
| Group | Sal + Veh | N + Sal | Veh + Qui | Naf + Qui | |
|---|---|---|---|---|---|
| Accuracy (%) | HI | 74.3 ± 6.2 | 77.8 ± 3.0 | 71.8 ± 8.7 | 79.0 ± 3.0 |
| LI | 82.9 ± 3.9 | 85.1 ± 5.9 | 84.4 ± 4.5 | 74.2 ± 2.5 | |
| Omission (%) | HI | 8.4 ± 3.1 | 4.3 ± 0.8 | 9.5 ± 3.1 | 4.6 ± 2.0 |
| LI | 8.7 ± 2.8 | 2.75 ± 1.4 | 4.5 ± 1.0 | 10.7 ± 6.7 | |
| Perseveration | HI | 113.8 ± 15.5 | 84.4 ± 12.5 | 65.6 ± 16.6 | 98.6 ± 15.7 |
| LI | 72.7 ± 8.6 | 58.7 ± 15.8 | 79.5 ± 9.7 | 70.7 ± 20.6 | |
| Correct response latency (s) | HI | 0.63 ± 0.13 | 0.61 ± 0.05 | 0.73 ± 0.23 | 0.67 ± 0.10 |
| LI | 0.57 ± 0.01 | 0.57 ± 0.07 | 0.54 ± 0.03 | 0.62 ± 0.06 | |
| Magazine latency (s) | HI | 1.69 ± 0.15 | 1.61 ± 0.06 | 2.46 ± 0.77 | 1.81 ± 0.08 |
| LI | 1.46 ± 0.19 | 1.75 ± 0.52 | 1.57 ± 0.16 | 1.96 ± 0.46 |
Doses are expressed as micrograms per 0.5 μl. Data are means ± SEM