Figure 4.

Chebulagic acid treatment relieved symptoms of EV71-infected mice. (A) The body weight of the infected mice treated with the placebo or chebulagic acid (1 mg/kg) was recorded in independent experiments (n = 20); (B) Clinical scores were systematically evaluated; (C) The typical phenotype of ruffled hair and paralysis of hind limbs caused by EV71 infection at 5 and 8 dpi (indicated by arrow) was shown, and the symptoms were prevented in the chebulagic acid treatment group (* p < 0.05, ** p < 0.01, *** p < 0.005).