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. 2013 May 7;14(5):9779–9789. doi: 10.3390/ijms14059779

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© 2013 by the authors; licensee MDPI, Basel, Switzerland

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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GCG-induced inhibitory effect on tetrodotoxin-resistant Na⁺ currents in rat dorsal root ganglia (DRG) neurons. (A) Example time courses of tetrodotoxin-resistant Na⁺ current in the absence (unfilled circles) and presence of 1 μM GCG (filled circles); (B) Representative tetrodotoxin-resistant Na⁺ currents in rat DRG neurons; (C) The blockade of tetrodotoxin-resistant Na⁺ currents after treatment with 1 μM GCG for 5 min (n = 6); (D) Concentration-response curve of tetrodotoxin-resistant Na⁺ currents inhibition by GCG (n = 4).