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. 2013 May 17;14(5):10369–10382. doi: 10.3390/ijms140510369

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© 2013 by the authors; licensee MDPI, Basel, Switzerland

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Liposome-encapsulated clodronate (LC) depleted almost all the M2 in the peritoneum without an effect on M1. (A) The number of M1 didn’t change among the four groups. Blue corresponds to nuclear staining, green corresponds to F4/80 and red corresponds to CCR7; co-location signals were identified as M1; (B) The number of M2 significantly increased after injecting Lactate-4.25% dialysate; liposome-encapsulated PBS (LP) didn’t affect M2 infiltration, but LC depleted peritoneal M2 efficiently. Blue corresponds to nuclear staining, green corresponds to F4/80 and red corresponds to CD206; co-location signals were identified as M2; (C) TGF-β was expressed by M2, and LC inhibited the expression of TGF-β by depletion of M2. Blue corresponds to nuclear staining, green corresponds to F4/80, red corresponds to CD206 and yellow corresponds to TGF-β staining.

Liposome-encapsulated clodronate (LC) depleted almost all the M2 in the peritoneum without an effect on M1. (A) The number of M1 didn’t change among the four groups. Blue corresponds to nuclear staining, green corresponds to F4/80 and red corresponds to CCR7; co-location signals were identified as M1; (B) The number of M2 significantly increased after injecting Lactate-4.25% dialysate; liposome-encapsulated PBS (LP) didn’t affect M2 infiltration, but LC depleted peritoneal M2 efficiently. Blue corresponds to nuclear staining, green corresponds to F4/80 and red corresponds to CD206; co-location signals were identified as M2; (C) TGF-β was expressed by M2, and LC inhibited the expression of TGF-β by depletion of M2. Blue corresponds to nuclear staining, green corresponds to F4/80, red corresponds to CD206 and yellow corresponds to TGF-β staining.